Regeneration Research in Diabetes

In both type 1 diabetes and advanced type 2 diabetes, insulin-producing beta cells lose their ability to function or perish completely. As a result, no or insufficient insulin is produced, resulting in permanently high blood glucose levels. Despite modern drug therapies, it is not always possible to completely normalize and prevent fluctuations in blood glucose levels. None of today's therapies stops the course of the disease or leads to the cure of the various forms of diabetes. As a result, up to fifty percent of patients still suffer from chronic secondary diseases and serious complications such as stroke, chronic renal failure, coronary heart disease, nerve and eye disease.

     

Kurz erklärt:

Ziel der Regenerationsforschung bei Diabetes ist es, Betazellen zu erhalten oder zu ersetzen. Wird Insulin bedarfsgerecht ausgeschüttet, verhindert dies Folgeerkrankungen.

To prevent such secondary diseases, researchers around the world are looking for ways to preserve or restore beta-cell mass in order to normalize insulin secretion. Promising approaches include

  • Cell replacement therapy: Insulin-producing islet cells are to be generated from stem cells.
  • The regeneration of the body's own beta cells. Scientists are working on techniques to regenerate or preserve remaining beta cells.

Hier befindet sich ein Video von Vimeo. Mit Ihrer Zustimmung wird eine Verbindung zu Vimeo aufgebaut. Vimeo setzt gegebenenfalls auch Cookies ein. Für weitere Informationen klicken Sie hier.

Regenerative Therapien eröffnen Chancen auf Heilung - bei Typ-1- und auch bei Typ-2-Diabetes. Prof. Heiko Lickert, Leiter des Instituts für Diabetes- und Regenerationsforschung am Helmholtz Zentrum München, erklärt im Videointerview die unterschiedlichen Strategien. Dauer: 2.33 Minuten

REGENERATION: BASICS: The beta cells are the insulin-producing cells in the pancreas. They are not distributed throughout the tissue, but are grouped in specific regions of the organ ...read more

REGENERATION: FUTURE APPLICATION AREAS: Stem cells are the hope of modern medicine. They possess a high self-renewal rate  ...read more

REGENERATION: RESEARCH: There are already a number of promising research approaches in regenerative diabetes research ...read more

Close
Informationen zum Inhalt

References

  • Tritschler, S. et al.: Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas. In: Mol Metab., 2017, 6(9):974-990. doi: 10.1016/j.molmet.2017.06.021. eCollection 2017 Sep. Review.
  • Bastidas-Ponce, A. et al.: Cellular and molecular mechanisms coordinating pancreas development. In: Development. 2017 Aug 15;144(16):2873-2888. doi: 10.1242/dev.140756.
  • Bastidas-Ponce, A.: Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. In: Mol Metab., 2017, 6(6):524-534. doi: 10.1016/j.molmet.2017.03.007. eCollection 2017 Jun.
  • Lickert, H., Kaestner, K.H.: Islet biology. In: Mol Metab., 2017, 6(9):vi. doi: 10.1016/j.molmet.2017.06.005. eCollection 2017 Sep 
  • Kleinert, M. et al.: Animal models of obesity and diabetes mellitus. In: Nat Rev Endocrinol., 2018, 14(3):140-162. doi: 10.1038/nrendo.2017.161.
  • Wang, X. et al: Genome-wide analysis of PDX1 target genes in human pancreatic progenitors. In: Mol Metab., 2018, 9:57-68. doi: 10.1016/j.molmet.2018.01.011.
  • Wang, X. et al.: Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. In: Stem Cell Res., 2016, 17(2):292-295. doi: 10.1016/j.scr.2016.08.005.
  • Wang, X. et al: Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene. In: Stem Cell Res., 2016, 17(2):273-276. doi: 10.1016/j.scr.2016.08.004. Epub 2016 Aug 5.
  • Roscioni, S.S. et al.: Impact of islet architecture on β-cell heterogeneity, plasticity and function. In: Nat Rev Endocrinol., 2016, 12(12):695-709. doi: 10.1038/nrendo.2016.147. Epub 2016 Sep 2.
  • Migliorini, A. et al.: Targeting insulin-producing beta cells for regenerative therapy. In: Diabetologia. 2016 Sep;59(9):1838-42. doi: 10.1007/s00125-016-3949-9.
  • Bader, E. et al: Identification of proliferative and mature β-cells in the islets of Langerhans. In: Nature. 2016 Jul 21;535(7612):430-4. Epub 2016 Jul 11.
  • Willmann S.J. et al.: The global gene expression profile of the secondary transition during pancreatic development. In: Mech Dev. 2016 Feb;139:51-64. doi: 10.1016/j.mod.2015.11.004. 

Scientific advice: Prof. Dr. Heiko Lickert

Last Change

December, 13, 2018

Jump to top
Print

We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.